I have extremely narrow feet and high arches, so I was pleased to find the 5.10 Sapphire fit me well. The S-curve lacing makes them very easy to adjust and takes pressure off the instep. Because they're cut lower in the heel, you might consider these if you have Achilles' tendon problems -- significanly less pressure in that area than a typical "men's" shoe. The Sapphire is a great shoe for multi-pitch, as they're a fairly comfy, flexible all-around shoe. Expect about half a size of stretch.

Although the rubber itself held up well (I never needed to have them resoled), I wore these shoes out after a few months of regular (2-3 days a week gym climbing, occasional cragging) use. The rubber started delaminating from the rands after only three months, and shortly after that, the shoes lost their stiffness. Not so good for edging, but great for smearing.
I'd recommend these shoes if you have width problems with other climbing shoes, but I don't feel that I got my money's worth out of them. I probably won't buy another pair, and plan to look for a different brand of shoe for my next pair of all-around shoes.